Pin1 mutant

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August undefined, 2024

WebAug 2, 2024 · PIN1 adopts a NhaA fold; this fold was first observed in the bacterial Na + /H + antiporter 27 and is shared by mammalian Na + /H + exchangers 28 and apical sodium-dependent bile acid transporter... WebThe pin1 mutant has fused cotyledons that appear as a cup on top of the hypocotyl/root axis; thus, the mutant shows loss of bilateral symmetry, but not apical-basal polarity …

Stems of the Arabidopsis pin1-1 mutant are not deficient …

WebPin1 enhances tumorigenesis in a Li-Fraumeni mouse model and cooperates with mutant p53 in Ras-dependent transformation. In breast cancer cells, Pin1 promotes mutant p53 dependent inhibition of the antimetastatic factor p63 and induction of a mutant p53 transcriptional program to increase aggressiveness. WebMay 26, 2005 · Clearly, pin1-1 is a key developmental mutant, and data on its endogenous IAA levels are critical. Surprisingly, such data are rare, especially for individual plant parts. The results of Reinhardt et al. imply … filling station lewiston mi menu

PIN1 - Wikipedia

WebWe tested the polar transport activity of indole-3-acetic acid and the endogenous amount of free indole-3-acetic acid in the tissue of inflorescence axes of the pin1 mutants and wild … WebJun 21, 2012 · When the pin1 mutant is combined with mutants in AUX1 and LAX1, the two proteins that are coexpressed with PIN1 in the L1 surface layer, the triple mutant … WebJun 17, 2013 · PIN1 down-regulation and pin1-5 mutation severely affect female gametophyte development since embryo sacs arrest at the mono- and/or bi-nuclear stages (FG1 and FG3 stage). PIN3 function is not required for ovule development in wild-type or PIN1 -silenced plants. filling station longniddry

A Guide to PIN1 Function and Mutations Across Cancers

PIN-FORMED1 and PINOID regulate boundary formation and …

WebJan 1, 2024 · PIN1 is a key effector involved in the Kras/ERK axis, synergistically mediating various cellular events. However, the underlying mechanism by which PIN1 promotes the development of PDAC remains unclear. Here we sought to elucidate the effect of PIN1 on redox homeostasis in Kras-driven PDAC. WebJan 17, 2024 · mutant. (C) Schematic showing PIN1 structure in the plasma membrane, with a cytosolic loop. (D) Brief history of key studies leading to the ﬁnding of PINs as direct targets of NPA (partly... groundhog doesn\u0027t see its showWebParkinson disease. Researchers have identified more than 70 mutations in the PINK1 gene that can cause Parkinson disease, a condition characterized by progressive problems … filling station lee\u0027s summit

"WebPIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depending on the cellular context, it also acts as a tumor suppressor. Here, we review … " - Pin1 mutant

Pin1 mutant

WebApr 8, 2024 · Liu et al. reported that an IRAK1-PIN1 axis enhances intrinsic tumor resistance to radiation therapy in p53 mutant zebrafish, human cancer cell lines, and mouse xenografts . However, very little is known about the effects of IRAK1 on tumor radioresistance and malignant behaviors in glioma. WebJun 1, 2024 · We demonstrate that Pin1 cooperates with mutant KRAS to promote transformation in PDAC, and that Pin1 inhibition impairs cell viability over time in PDAC cell lines. Main Proline-directed...

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Web乳腺癌的P_（53）表达姚品芳，毛永荣P53基因的突变或缺失是许多肿瘤发生的原因。P53蛋白产物P53蛋白是一种核蛋白，分子量为53kd，主要分布在恶性肿瘤细胞核内。近两年巳。蛋白通过免疫组化方法在肿瘤中的定位文献报道已非常活跃，本实验应用免疫组化方?.. WebThe pin1-1 mutant of Arabidopsis thaliana has been pivotal for studies on auxin transport and on the role of auxin in plant development. It was reported previously that when whole …

WebJul 12, 2011 · A Pin1/ mutant p53 axis evokes aggressiveness in breast cancer through the inhibition of p63-regulated expression of Dicer [34, 39], and p53 mutants can prevent DEPDC1 (DEP domain containing 1 ... WebMar 25, 2015 · To investigate the differential response of pin1 and pin2 mutants under low-B conditions, the effect of low-B on PIN1–green fluorescent protein (GFP) and PIN2–GFP …

WebJun 1, 2024 · We demonstrate that Pin1 cooperates with mutant KRAS to promote transformation in PDAC, and that Pin1 inhibition impairs cell viability over time in PDAC … Webp53 protein is a well-known tumor suppressor factor that regulates cellular homeostasis. As it has several and key functions exerted, p53 is known as “the guardian of the genome” and either loss of function or gain of function mutations in the TP53 coding protein sequence are involved in cancer onset and progression. The Hippo pathway is a key regulator of …

WebJul 13, 2024 · Despite the large number of cellular targets, PIN1 null mice are viable 43. In in vivo models of cancer, PIN1 null mice are resistant to several oncogenic drivers, including mutant RAS; conversely, PIN1 overexpression can increase RAS-driven phenotypes, suggesting that PIN1 is an important mediator of RAS signaling 27.

WebJan 20, 2015 · When PIN1 is expressed under the control of the PIN2 promoter in the agravitropic pin2 mutant, it is, in contrast to PIN2, localized predominantly basally (toward root tip) in epidermis cells. Therefore, the auxin transport capacity in basipetal (shootward) direction, necessary for correct gravitropism, is not achieved. filling station menu beaufort scWebSep 5, 2013 · A semi-dominant mutant was identified by its smaller and dramatically down-curling leaf phenotype, and thus designated as curlyfolia1-D ( cuf1-D) and subsequently as idd14-1D (see below) ( Figure 1A ). To examine the genetic nature of cuf1-D, we backcrossed cuf1-D with wild type (WT) plants. groundhog doesn\u0027t see its shadowllllWebOct 15, 2004 · Single mutations in the PIN-FORMED1 ( PIN1) and PINOID ( PID )genes, which mediate auxin-dependent organ formation, moderately disrupt the symmetric … groundhog does see its shadowllllWebOur results suggest that PIN1 plays a role in cancer cell proliferation, migration and invasion in a different manner according to the TP53 gene mutation status in HCC. In particular, interaction of PIN1 with mutant TP53 can act as a tumor promoter and increase its oncogenic activities in HCC. MeSH terms Adult filling station menu longniddryWebAug 26, 2024 · The first PIN to be cloned was PIN1 from Arabidopsis thaliana. The pin1 mutant exhibited defective inflorescence development, lacked cauline leaves and floral organs, and had a pin-head trait . Subsequently, seven more … groundhog does see its shadowmmmmWebNational Center for Biotechnology Information filling station lavale facebookWebDec 31, 2024 · Phenotypic observations and statistics of HJ2 and different pin1 mutants. (a) Phenotypes of 7-day-old seedlings of HJ2, pin1c pin1d double mutant (pin1cd), pin1a pin1c pin1d triple mutant (pin1acd ... filling station menu rockford illinois