WebThis multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. 2 publications Catalytic activity WebWelcome to PomBase A comprehensive database for the fission yeast Schizosaccharomyces pombe, providing structural and functional annotation, literature curation and access to large-scale data sets Gene summary Gene standard name lys1 Systematic ID SPAP7G5.04c Product aminoadipate-semialdehyde dehydrogenase …

PDB 2kr5 structure summary ‹ Protein Data Bank in Europe (PDBe) …

WebAcyl carrier protein (ACP) is a universal and highly conserved carrier of acyl intermediates during fatty acid synthesis. In yeast and mammals, ACP exists as a separate domain within a large multifunctional fatty acid synthase polyprotein (type I FAS), whereas it is a small monomeric protein in bacteria and plastids (type II FAS). WebJun 2, 2011 · Introduction. One of the most distinctive features of fatty acid, nonribosomal peptide and polyketide biosynthetic pathways is the utilization of the acyl carrier protein (ACP) or peptidyl carrier protein (PCP) for the shuttling of biosynthetic intermediates among various catalytic domains or proteins –.The small and highly dynamic ACPs or PCPs can … diamondback firearms cocoa florida

Molecular basis for acyl carrier protein–ketoreductase interaction in

WebIts crystal structure contains five catalytic domains, two nonenzymatic domains and a shuttle protein domain. Overexpression in FAS can be linked to development of cancer cells (1). Activity of fatty acid synthase (FAS) in mammals is often low in most body tissue. The acyl carrier protein (ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. It is one of the most abundant proteins in cells of E. coli. In both cases, the growing chain is bound to the ACP via a thioester derived from the distal thiol of a 4'-phosphopantetheine moiety. WebJul 10, 2024 · ACP3 is a four-helix bundle with S38 being unmodified in the apo form of the protein, phosphopantheine bound in the holo form, and with polyketide substrate attached to the phosphopantetheine in the acyl bound form. The protein backbone is shown as ribbon, with the S38 side chain and bound substrate shown as atoms with standard CPK colorings. diamondbackfirearms.com